
Methadone is a synthetic (man-made) narcotic. It is used legally to treat addiction to narcotics and to relieve severe pain, often in individuals who have cancer or terminal illnesses. Although methadone has been legally available in the United States since 1947, more recently it has emerged as a drug of abuse. This trend may be driven in part by the ready availability of the drug as it increasingly is used in the treatment of narcotic addiction and to relieve chronic pain.
Methadone comes in tablets, oral solution, and injectable liquid.
Some methadone tablets are designed to be swallowed intact, while others are intended to be dissolved first in liquid. Likewise, methadone is available either as a ready-to-drink solution or as a concentrate, which must be mixed first with water or fruit juice. Methadone also is available as a liquid that is administered via injection.
When used to treat narcotic addiction, methadone suppresses withdrawal symptoms for 24 to 36 hours.
Individuals who are prescribed methadone for treatment of heroin addiction experience neither the cravings for heroin nor the euphoric rush that are typically associated with use of that drug.
Methadone overdoses are associated with severe respiratory depression, decreases in heart rate and blood pressure, coma, and death. The Drug Abuse Warning Network reports that methadone was involved in 10,725 emergency department visits in 2001--a 37 percent increase from the previous year.
Street Terms for Methadone
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Abusing methadone is illegal. Methadone is a Schedule II substance under the Controlled Substances Act. Schedule II drugs, which include cocaine and methamphetamine, have a high potential for abuse.
Individuals who abuse methadone risk becoming tolerant of and physically dependent on the drug. When these individuals stop using the drug they may experience withdrawal symptoms including muscle tremors, nausea, diarrhea, vomiting, and abdominal cramps.

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